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This is the first
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controlled study to assess therapeutic efficacy of topical 5%
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Imiquimod ( Aldara ) cream in persistent warts associated with immunosuppression. Trachomatis (MoPn) infection in the murine model.. Similar efficacy in cutaneous warts is not yet established. best antibiotic sinus infection (http://isaac.ssl.berkeley.edu/cplan/view_profile.php?userid=1474t=aldara) oral or vaginal administration of the immune response modifier Imiquimod ( Aldara ) would decrease vaginal shedding of Chlamydia trachomatis, mouse pneumonitis strain (MoPn), in a murine model. Imiquimod ( Aldara ) is a potent inducer of antiviral
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cytokine activity which has shown significant
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efficacy in the treatment of anogenital warts. Imiquimod ( Aldara ) cream 5% for recalcitrant cutaneous warts in
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immunosuppressed individuals.BACKGROUND. To assess the response of persistent cutaneous warts to 5% Imiquimod ( Aldara ) cream in immunosuppressed individuals. Viral warts may cause significant morbidity in individuals unable to mount an adequate T-helper 1 cell-mediated immune response to human papillomavirus. Imiquimod ( Aldara ) does not affect shedding of viable chlamydiae in a murine model
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of Chlamydia trachomatis genital tract infection.OBJECTIVE. Fifteen immunosuppressed patients with warts
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on the hands and/or feet present for more than 18 months, which had failed to respond to a minimum of 12 weeks of
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topical salicylic acid and four cycles of cryotherapy, were recruited. Left comparison study for
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24 weeks (three times weekly for 8 weeks, daily for 8 weeks, then daily with occlusion for 8 weeks). Benefit was seen in five patients [36% in the intent-to-treat analysis (14 patients)], including more than 30% clearance of warts in three patients and reduction
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in overall size of warts in two further cases.

Female BALB/c mice were infected intravaginally with C. Twelve (80%) patients completed the study protocol. Imiquimod ( Aldara ) 5% cream was applied in an open label, right vs. There was no significant difference in the course of infection when Imiquimod ( Aldara )-treated mice were compared with sham-treated controls, regardless of whether the drug was administered orally or vaginally.

Local skin reactions occurred in four (29%) patients and were usually mild. IgG subclass antibody responses, and by extension, T helper type 1 to T helper type 2 immune response polarization, were also unaffected. A transient rise in creatinine (11-29% above
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baseline) was measured in three renal transplant recipients, but we did not consider that this was related to Imiquimod ( Aldara ) exposure. The course of infection was monitored by collecting cervical-vaginal swabs and isolation in HeLa 229 cell culture. Imiquimod ( Aldara ) has no efficacy
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in controlling C. Trachomatis (MoPn) and were administered Imiquimod ( Aldara ) either orally (30 mg/kg) or vaginally (10 microl of 5% Imiquimod ( Aldara ) cream) prior to infection and every second day after infection for a total of four doses. It provides preliminary evidence that topical Imiquimod ( Aldara ) may benefit a subgroup of immunosuppressed patients with recalcitrant cutaneous warts.


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